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Search Results for " mda 9 "

Targets Recommended: NF-κB

4

抑制剂 & 化合物

3

天然产物

7

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T82022	IVMT-Rx-3	NF-κB	NF-κB
	IVMT-Rx-3是针对SDCBP的PDZ1和PDZ2结构域，特别是MDA-9/Syntenin的抑制剂。该化合物能够中断MDA-9/Syntenin与Src之间的互动，减少NF-κB的激活，并且降低MMP-2/MMP-9的表达量，从而抑制了黑色素瘤的转移。
T79651	EGFR-IN-83	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	EGFR-IN-83（化合物9）为EGFR抑制剂，IC50为2.53 nM。该化合物对MCF-7及MDA-MB-231细胞显示出抗增殖作用，其IC50值分别为2.50 μM及1.96 μM。此外，EGFR-IN-83能够诱导细胞凋亡。
T63797	PDZ1i
	PDZ1i 是有效的、能够透过血脑屏障的 MDA-9/Syntenin 特异性抑制剂。PDZ1i 能够抑制关键的 GBM (多形性成胶质细胞瘤)信号，包括 FAK 及 EGFRvIII，并能够减少 MMP 分泌。PDZ1i 可以提高患脑瘤小鼠的生存率并减少肿瘤的侵袭。
T36201	AZD5582 dihydrochloride AZD 5582 dihydrochloride
	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice. Hennessy et al (2013) Discovery of a novel class of dimeric Smac mimetics as potent IAP...

化合物

Cat.No: T82022

Target: NF-κB

Cat.No: T79651

Target: EGFR

Cat.No: T63797

AZD5582 dihydrochloride

Cat.No: T36201

Synonym: AZD 5582 dihydrochloride

Cat. No.	Product Name	Target	Signaling Pathways
T2973	Astragaloside IV AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV	MMP; ERK; Estrogen/progestogen Receptor; JNK	Endocrinology/Hormones; MAPK; Proteases/Proteasome
	Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷，抑制ERK1/2和JNK 激活，在乳腺癌细胞 MDA-MB-231 中，下调(MMP)-2和(MMP)-9的信号通路。
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。

天然产物

Astragaloside IV

Cat.No: T2973

Synonym: AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV

Target: MMP, ERK, Estrogen/progestogen Receptor, JNK

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04817	Syntenin Protein, Human, Recombinant (His) MDA-9,SYCL,TACIP18,syndecan binding protei...	Human	E. coli
	Syntenin1/SDCBP (syndecan binding protein), also known as melanoma differentiation associated gene-9 (MDA-9), is a PDZ domain-containing molecule, which was initially identified as a key oncogene in melanoma. IL-6 promotes glioma cell proliferation and invasion by inducing SDCBP expression, which is mediated by JAK2/STAT3 signaling. SDCBP might be an important marker for identifying Triple negative breast cancer (TNBC) cases that are suitable for dasatinib therapy.
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698	VEGF121b Protein, Human, Recombinant MVCD1,VEGF,VPF,vascular endothelial growth factor A	Human	HEK293 Cells
	VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005	YAP1 Protein, Human, Recombinant (Isoform 9, His) YAP1-2delta	Human	P. pastoris (Yeast)
	YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825	VEGF121 Protein, Human, Recombinant (His & Avi) VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826	VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated NRCAML,neurofascin,NF	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

Syntenin Protein, Human, Recombinant (His)

Cat.No: TMPY-04817

Species: Human

Expression System: E. coli

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

VEGF121b Protein, Human, Recombinant

Cat.No: TMPY-03698

Species: Human

Expression System: HEK293 Cells

YAP1 Protein, Human, Recombinant (Isoform 9, His)

Cat.No: TMPH-00005

Species: Human

Expression System: P. pastoris (Yeast)

VEGF121 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00825

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00826

Species: Human

Expression System: HEK293 Cells

Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05268

Species: Human

Expression System: HEK293 Cells

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